Education



What are A.G.E.s?

Advanced glycation end-products (A.G.E.s) are harmful oxidative compounds that play a significant role in many chronic diseases. A.G.E.s are formed in our bodies when sugar combines with fat, protein and even genetic material in a process known as glycation. In addition to A.G.E.s that are formed endogenously in the body, A.G.E.s are also consumed in the foods we eat. Methods of cooking and preparing foods alters their A.G.E. content. More highly processed foods, as well as foods that are cooked at higher temperatures through grilling, broiling, roasting and frying will dramatically increase levels of A.G.E. formation. 

How are A.G.E.s formed?

A.G.E.s are created in the body as we break down nutrients to provide energy for our bodies to work. They are also found naturally in the foods we eat every day. In both cases, they are formed when sugar comes into contact with proteins, fats and DNA. This process in known as glycation. Methods of cooking and preparing foods alters their A.G.E. content. The heat applied both during cooking and in the preparation and manufacturing of more highly processed foods causes more glycation to occur, and in turn, substantially increases their A.G.E. content. On the other hand, raw or minimally processed foods typically have a lower A.G.E. content in comparison. 

How do A.G.E.s impact our health?

Our bodies are only capable of eliminating a fraction of the A.G.E.s they are exposed to, and over time these chemicals accumulate in our tissues and organs, causing increased oxidative stress and inflammation. To make matters worse, the increased oxidative stress and inflammation can then lead to production of more A.G.E.s which perpetuate the cycle. This causes our tissues and organs to grow older more quickly. As a result, high A.G.E. levels in the body are linked to the development of many chronic illnesses, such as heart disease, kidney failure, diabetes, Alzheimer’s and premature aging. On the other hand, low A.G.E. levels have been linked to accelerated wound healing, decreased inflammation and oxidative stress, improved insulin sensitivity, and even a longer lifespan.  It is clear that A.G.E.s play a substantial role in the development of chronic diseases, and therefore monitoring A.G.E. levels should be considered as an important marker of overall health.

What can we do to Interrupt the A.G.E.s Invasion?

Good news! Research has given us real insights into how we can reduce our risks and exposure to A.G.E.s. The first step is spreading understanding and awareness. Staying away from foods that inherently have high A.G.E. levels, in conjunction with using low - A.G.E. methods of food preparation will significantly lower the total A.G.E. stores within our bodies. It is clear that A.G.E.s play a substantial role in the development of chronic disease, and therefore monitoring of A.G.E. levels should be considered as a marker of overall health.

There's solid early-stage evidence that in limited human and animal studies that ProLiv's key probiotic compound Lactococcus Lactis KF140 can reduce post-meal CML (key dietary AGE) spikes potentially lowering the inflammatory / metabolic burden of AGEs. Additionally, KF140 significantly reduced serum CML levels, lowered liver CML absorption, and even attenuated high-fat / CML-induced fatty liver disease and metabolic disturbances.

What is Lactococcus Lactis KF140?

Lactococcus Lactis KF140 is a strain of lactic acid bacteria that has garnered attention in the field of microbiology and health sciences. This specific strain is part of the Lactococcus genus, which is known for its role in fermentation processes and its potential health benefits. Research indicates that Lactococcus KF140 may contribute positively to gut health, immune function, and overall well-being.

One of the primary functions of Lactococcus KF140 is its ability to produce lactic acid, which can help maintain an optimal pH level in the gastrointestinal tract. This acidic environment is conducive to the growth of beneficial bacteria while inhibiting the proliferation of pathogenic microorganisms. Studies have shown that the presence of Lactococcus KF140 can enhance the microbial diversity of the gut, which is essential for a balanced microbiome.

In terms of immune support, Lactococcus KF140 has been observed to stimulate the production of immunoglobulins and other immune-related compounds. This stimulation can lead to a more robust immune response, potentially reducing the incidence of infections and enhancing the body's ability to combat pathogens. Research suggests that regular consumption of probiotics, including Lactococcus KF140, may lead to a 20-30% reduction in the frequency of upper respiratory tract infections.

Furthermore, Lactococcus KF140 may play a role in metabolic health. Some studies indicate that this strain can influence lipid metabolism and glucose regulation, which are critical factors in the management of metabolic disorders such as obesity and type 2 diabetes. The modulation of these metabolic pathways can lead to improved insulin sensitivity and a reduction in body fat percentage, contributing to overall health and longevity.

It is important to note that the efficacy of Lactococcus KF140, like other probiotics, can be influenced by various factors, including dosage, duration of intake, and individual health status. Clinical trials have demonstrated that a daily intake of 10 billion CFUs (colony-forming units) of Lactococcus KF140 can yield significant health benefits, particularly in individuals with compromised gut health or those seeking to enhance their immune function.

Lactococcus KF140 represents a promising probiotic strain with potential applications in promoting gut health, supporting immune function, and improving metabolic outcomes. 

What is the Gut-Liver Axis?

The gut-liver axis is the bi-directional communication system between your gastrointestinal tract (gut) and your liver.  This system plays a vital role in digestion, detoxification, metabolism, and immune regulation.

How does the Gut-Liver Work?

  1. Nutrient & Toxin flow - Everything absorbed in your gut (nutrients, bacteria, toxins) travels to the liver via the portal vein - your liver's direction to your gut.  The liver processes these substances: detoxifying harmful ones, storing or converting nutrients , and releasing safe byproducts into the bloodstream or bile.
  2. Immune and Inflammatory Signals - The gut microbiome produces signals that influence inflammation, immunity, and metabolic balance.  A healthy microbiome promotes tolerance and low inflammation.  A disrupted one ("dysbiosis") sends danger signals, triggering liver stress and systemic inflammation.
  3. Barrier Integrity - The intestinal barrier keeps harmful bacteria and toxins in the gut.  When compromised ("leaky gut") these enter the bloodstream and reach the liver, causing liver inflammation, fat accumulation, and potentially fibrosis.

How do we support it?

Probiotics & Prebiotics to balance the gut bacteria

Polyphenols & Fiber to reduce gut inflammation and support detox

Liver nutrients like tocotrienols, choline, and antioxidants to protect liver cells